| 2. Jornada | 25.04.2010 | Columbus Crew | - | Real Salt Lake | 1:0 | ||||
| 3. Jornada | 02.05.2010 | Seattle Sounders | - | Columbus Crew | 1:1 | ||||
| 3. Jornada | 21.05.2010 | New York RB | - | Columbus Crew | 1:3 | ||||
| 3. Jornada | 23.05.2010 | Kansas City Wizards | - | Columbus Crew | 0:1 | ||||
| 3. Jornada | 30.05.2010 | Columbus Crew | - | Los Angeles Galaxy | 0:2 |  |
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| 4. Jornada | 03.06.2010 | San Jose Earthquakes | - | Columbus Crew | 2:2 | |
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| 4. Jornada | 06.06.2010 | Colorado Rapids | - | Columbus Crew | 1:0 | ||||
| 5. Jornada | 25.07.2010 | Columbus Crew | - | Houston Dynamo | 3:0 |
Estados Unidos