| 5. Jornada | 09.08.2021 | San Jose Earthquakes | - | Los Angeles FC | 2:1 |  |
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| 5. Jornada | 14.08.2021 | San Jose Earthquakes | - | Vancouver Whitecaps | 0:0 | ||||
| 5. Jornada | 18.08.2021 | San Jose Earthquakes | - | Minnesota United FC | 1:1 | ||||
| 5. Jornada | 21.08.2021 | Los Angeles Galaxy | - | San Jose Earthquakes | 1:2 |  |
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| 6. Jornada | 05.09.2021 | San Jose Earthquakes | - | Colorado Rapids | 0:1 | ||||
| 7. Jornada | 16.10.2021 | Los Angeles FC | - | San Jose Earthquakes | 3:1 | ||||
| 7. Jornada | 21.10.2021 | San Jose Earthquakes | - | Austin FC | 4:0 | ||||
| 7. Jornada | 24.10.2021 | San Jose Earthquakes | - | Vancouver Whitecaps | 1:1 | ||||
| 7. Jornada | 28.10.2021 | Portland Timbers | - | San Jose Earthquakes | 2:0 | ||||
| 7. Jornada | 30.10.2021 | Real Salt Lake | - | San Jose Earthquakes | 3:4 | ||||
| 8. Jornada | 08.11.2021 | San Jose Earthquakes | - | FC Dallas | 1:1 |
Francia
Camerún