| 2. Jornada | 10.08.2021 | UNAN Managua | - | H&H Export Sébaco | 0:2 | ||||
| 3. Jornada | 15.08.2021 | H&H Export Sébaco | - | Club Deportivo Ocotal | 0:1 | ||||
| 4. Jornada | 22.08.2021 | H&H Export Sébaco | - | Managua FC | 0:0 | ||||
| 5. Jornada | 29.08.2021 | Juventus Managua | - | H&H Export Sébaco | 1:0 | ||||
| 6. Jornada | 03.09.2021 | ART Municipal Jalapa | - | H&H Export Sébaco | 0:2 |  |
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| 7. Jornada | 12.09.2021 | H&H Export Sébaco | - | CD Walter Ferretti | 4:8 | ||||
| 9. Jornada | 26.09.2021 | Real Madriz | - | H&H Export Sébaco | 3:3 | ||||
| 11. Jornada | 10.10.2021 | H&H Export Sébaco | - | UNAN Managua | 1:1 | ||||
| 12. Jornada | 16.10.2021 | Club Deportivo Ocotal | - | H&H Export Sébaco | 1:1 | ||||
| 15. Jornada | 31.10.2021 | CD Walter Ferretti | - | H&H Export Sébaco | 2:1 | ||||
| 16. Jornada | 04.11.2021 | H&H Export Sébaco | - | ART Municipal Jalapa | 3:0 | ||||
| 17. Jornada | 17.11.2021 | H&H Export Sébaco | - | Diriangén FC | 1:1 |
Nicaragua