| 2. Jornada | 31.07.2021 | Club León [Sub 20] | - | Club Tijuana [Sub 20] | 2:1 |  |
|||
| 3. Jornada | 05.08.2021 | Gallos Blancos [Sub 20] | - | Club León [Sub 20] | 1:0 | ||||
| 6. Jornada | 21.08.2021 | Club León [Sub 20] | - | Santos Laguna [Sub 20] | 1:1 | ||||
| 7. Jornada | 28.08.2021 | Club León [Sub 20] | - | CF América [Sub 20] | 2:2 | ||||
| 12. Jornada | 02.10.2021 | Club León [Sub 20] | - | Atlético San Luis [Sub 20] | 2:0 | ||||
| 13. Jornada | 16.10.2021 | CF Monterrey [Sub 20] | - | Club León [Sub 20] | 1:1 | ||||
| 14. Jornada | 20.10.2021 | Club León [Sub 20] | - | Pumas UNAM [Sub 20] | 0:2 | ||||
| 15. Jornada | 23.10.2021 | Puebla FC [Sub 20] | - | Club León [Sub 20] | 2:1 | ||||
| 16. Jornada | 31.10.2021 | Deportivo Toluca [Sub 20] | - | Club León [Sub 20] | 1:0 | ||||
| 17. Jornada | 06.11.2021 | Club León [Sub 20] | - | Club Necaxa [Sub 20] | 3:1 |
México