| 1. Jornada | 24.07.2021 | CF Monterrey [Sub 16] | - | Santos Laguna [Sub 16] | 4:4 | ||||
| 3. Jornada | 07.08.2021 | Santos Laguna [Sub 16] | - | UANL Tigres [Sub 16] | 3:1 | ||||
| 7. Jornada | 04.09.2021 | Santos Laguna [Sub 16] | - | Club León [Sub 16] | 1:0 | ||||
| 17. Jornada | 13.11.2021 | Santos Laguna [Sub 16] | - | Deportivo Guadalajara [Sub 16] | 0:1 |
México