| 2. Jornada | 14.03.2021 | Atlético Palmaflor | - | Real Santa Cruz | 1:0 | ||||
| 1. Jornada | 28.03.2021 | Real Santa Cruz | - | Jorge Wilstermann | 0:2 | ||||
| 3. Jornada | 03.04.2021 | Real Santa Cruz | - | Always Ready | 2:3 | ||||
| 4. Jornada | 09.04.2021 | Royal Pari | - | Real Santa Cruz | 3:2 | ||||
| 6. Jornada | 02.05.2021 | CD Guabirá | - | Real Santa Cruz | 1:0 | ||||
| 7. Jornada | 07.05.2021 | Real Santa Cruz | - | Blooming | 1:0 |  |
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| 5. Jornada | 12.05.2021 | Real Santa Cruz | - | Real Potosí | 4:1 | |
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| 8. Jornada | 12.07.2021 | Bolívar | - | Real Santa Cruz | 1:1 | |
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| 9. Jornada | 17.07.2021 | Real Santa Cruz | - | Club Aurora | 1:1 | ||||
| 10. Jornada | 21.07.2021 | Real Tomayapo | - | Real Santa Cruz | 2:1 | ||||
| 14. Jornada | 07.08.2021 | Real Santa Cruz | - | Oriente Petrolero | 0:0 | ||||
| 15. Jornada | 15.08.2021 | The Strongest | - | Real Santa Cruz | 1:2 | |
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| 16. Jornada | 20.08.2021 | Jorge Wilstermann | - | Real Santa Cruz | 5:1 | |
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| 18. Jornada | 14.09.2021 | Always Ready | - | Real Santa Cruz | 4:0 |
Bolivia