| 1. Jornada | 08.01.2022 | Mazatlán FC [Sub 16] | - | Atlas Guadalajara [Sub 16] | 0:1 | ||||
| 3. Jornada | 22.01.2022 | Atlas Guadalajara [Sub 16] | - | CF Monterrey [Sub 16] | 2:2 | ||||
| 4. Jornada | 29.01.2022 | Atlético San Luis [Sub 16] | - | Atlas Guadalajara [Sub 16] | 0:1 | ||||
| 6. Jornada | 12.02.2022 | Santos Laguna [Sub 16] | - | Atlas Guadalajara [Sub 16] | 5:3 | ||||
| 15. Jornada | 16.04.2022 | Atlas Guadalajara [Sub 16] | - | Mazatlán FC [Sub 16] | 5:0 |  |
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| 16. Jornada | 23.04.2022 | Atlas Guadalajara [Sub 16] | - | Deportivo Guadalajara [Sub 16] | 2:2 | ||||
| 17. Jornada | 30.04.2022 | UANL Tigres [Sub 16] | - | Atlas Guadalajara [Sub 16] | 2:2 | ||||
| 18. Jornada | 07.05.2022 | Atlas Guadalajara [Sub 16] | - | Atlético San Luis [Sub 16] | 4:2 |
México