| 7. Jornada | 02.04.2022 | Real Santa Cruz | - | Oriente Petrolero | 2:1 |  |
|||
| 8. Jornada | 09.04.2022 | Atlético Palmaflor | - | Real Santa Cruz | 2:1 | ||||
| 10. Jornada | 22.04.2022 | CD Guabirá | - | Real Santa Cruz | 1:0 | |
|||
| 13. Jornada | 08.05.2022 | Always Ready | - | Real Santa Cruz | 5:0 | ||||
| 14. Jornada | 12.05.2022 | Club Aurora | - | Real Santa Cruz | 2:4 |
Bolivia