| 1. Jornada | 17.04.2021 | Orlando City | - | Atlanta United FC | 0:0 | ||||
| 1. Jornada | 24.04.2021 | Sporting Kansas City | - | Orlando City | 1:1 |  |
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| 2. Jornada | 02.05.2021 | Orlando City | - | FC Cincinnati | 3:0 | |
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| 2. Jornada | 09.05.2021 | Orlando City | - | New York City FC | 1:1 | ||||
| 2. Jornada | 17.05.2021 | D.C. United | - | Orlando City | 0:1 | ||||
| 2. Jornada | 23.05.2021 | Orlando City | - | Toronto FC | 1:0 | ||||
| 2. Jornada | 29.05.2021 | New York RB | - | Orlando City | 2:1 | |
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| 4. Jornada | 08.07.2021 | Chicago Fire | - | Orlando City | 3:1 | ||||
| 4. Jornada | 18.07.2021 | Toronto FC | - | Orlando City | 1:1 | ||||
| 6. Jornada | 26.09.2021 | New England Revolution | - | Orlando City | 2:1 | ||||
| 6. Jornada | 30.09.2021 | Nashville SC | - | Orlando City | 2:2 | ||||
| 7. Jornada | 03.10.2021 | Orlando City | - | D.C. United | 2:1 | ||||
| 7. Jornada | 21.10.2021 | Orlando City | - | CF Montréal | 1:1 | ||||
| 7. Jornada | 25.10.2021 | Orlando City | - | New England Revolution | 2:2 | ||||
| 7. Jornada | 28.10.2021 | Columbus Crew | - | Orlando City | 3:2 | |
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| 8. Jornada | 31.10.2021 | Orlando City | - | Nashville SC | 1:1 | |
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| 8. Jornada | 07.11.2021 | CF Montréal | - | Orlando City | 0:2 |  |
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Ecuador