| 1. Jornada | 27.02.2022 | Orlando City | - | CF Montréal | 2:0 | ||||
| 2. Jornada | 13.03.2022 | Orlando City | - | FC Cincinnati | 1:2 | ||||
| 2. Jornada | 19.03.2022 | Los Angeles Galaxy | - | Orlando City | 0:1 | ||||
| 3. Jornada | 09.04.2022 | Orlando City | - | Chicago Fire | 1:0 |  |
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| 3. Jornada | 17.04.2022 | Columbus Crew | - | Orlando City | 0:2 | ||||
| 3. Jornada | 24.04.2022 | Orlando City | - | New York RB | 0:3 | ||||
| 4. Jornada | 01.05.2022 | Orlando City | - | Charlotte FC | 2:1 | ||||
| 4. Jornada | 07.05.2022 | CF Montréal | - | Orlando City | 4:1 | ||||
| 4. Jornada | 14.05.2022 | Toronto FC | - | Orlando City | 0:1 | ||||
| 4. Jornada | 23.05.2022 | Austin FC | - | Orlando City | 2:2 | ||||
| 4. Jornada | 29.05.2022 | Orlando City | - | FC Dallas | 1:3 | |
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| 5. Jornada | 19.06.2022 | Orlando City | - | Houston Dynamo | 2:1 | ||||
| 6. Jornada | 05.07.2022 | Orlando City | - | D.C. United | 3:5 |
Ecuador