| 2. Jornada | 12.02.2022 | San Francisco FC | - | Independiente de La Chorrera | 2:0 |  |
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| 3. Jornada | 20.02.2022 | Atlético Chiriquí | - | San Francisco FC | 2:1 | ||||
| 4. Jornada | 26.02.2022 | San Francisco FC | - | UD Universitario | 0:1 | |
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| 5. Jornada | 05.03.2022 | Herrera FC | - | San Francisco FC | 0:0 | ||||
| 6. Jornada | 09.03.2022 | San Francisco FC | - | Árabe Unido | 0:0 | |
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| 8. Jornada | 21.03.2022 | Tauro FC | - | San Francisco FC | 1:0 | ||||
| 10. Jornada | 02.04.2022 | San Francisco FC | - | Plaza Amador | 2:2 | ||||
| 11. Jornada | 09.04.2022 | Potros del Este | - | San Francisco FC | 0:0 |
Colombia