| 1. Jornada | 09.02.2022 | Cerrito | - | Danubio | 0:1 |  |
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| 2. Jornada | 15.02.2022 | Deportivo Maldonado | - | Danubio | 1:2 | ||||
| 3. Jornada | 20.02.2022 | Danubio | - | Rentistas | 0:1 | ||||
| 4. Jornada | 26.02.2022 | Liverpool | - | Danubio | 0:1 | ||||
| 5. Jornada | 05.03.2022 | Danubio | - | Peñarol | 0:1 | |
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| 6. Jornada | 22.03.2022 | Montevideo City Torque | - | Danubio | 1:1 |  |
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| 10. Jornada | 23.04.2022 | River Plate | - | Danubio | 0:0 | ||||
| 13. Jornada | 22.05.2022 | Danubio | - | Defensor Sporting | 1:2 |
Nigeria