| 1. Jornada | 12.03.2021 | Real Tomayapo | - | Always Ready | 1:0 |  |
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| 5. Jornada | 25.04.2021 | Real Tomayapo | - | Blooming | 2:1 | ||||
| 6. Jornada | 02.05.2021 | Bolívar | - | Real Tomayapo | 2:0 | ||||
| 7. Jornada | 11.05.2021 | Real Tomayapo | - | Club Aurora | 1:2 | ||||
| 10. Jornada | 21.07.2021 | Real Tomayapo | - | Real Santa Cruz | 2:1 | ||||
| 11. Jornada | 25.07.2021 | Nacional Potosí | - | Real Tomayapo | 0:0 | ||||
| 12. Jornada | 01.08.2021 | Real Tomayapo | - | Oriente Petrolero | 0:1 | ||||
| 13. Jornada | 05.08.2021 | The Strongest | - | Real Tomayapo | 2:0 | ||||
| 14. Jornada | 08.08.2021 | Real Tomayapo | - | Jorge Wilstermann | 1:2 | ||||
| 15. Jornada | 14.08.2021 | Atlético Palmaflor | - | Real Tomayapo | 2:0 | ||||
| 16. Jornada | 17.08.2021 | Always Ready | - | Real Tomayapo | 3:1 | ||||
| 17. Jornada | 22.08.2021 | Real Tomayapo | - | Royal Pari | 1:4 |
Bolivia