| 10. Jornada | 02.10.2021 | Bohemians Praha 1905 | - | Sigma Olomouc | 2:0 | ||||
| 14. Jornada | 06.11.2021 | Viktoria Plzeň | - | Sigma Olomouc | 0:0 | ||||
| 16. Jornada | 27.11.2021 | FK Pardubice | - | Sigma Olomouc | 1:5 | ||||
| 17. Jornada | 04.12.2021 | Sigma Olomouc | - | Slavia Praga | 0:1 | ||||
| 18. Jornada | 12.12.2021 | Dynamo České Budějovice | - | Sigma Olomouc | 2:1 |  |
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| 19. Jornada | 19.12.2021 | Sigma Olomouc | - | FC Fastav Zlín | 1:1 | ||||
| 20. Jornada | 05.02.2022 | FK Jablonec | - | Sigma Olomouc | 1:0 | ||||
| 21. Jornada | 13.02.2022 | Sigma Olomouc | - | FK Mladá Boleslav | 2:1 | ||||
| 25. Jornada | 13.03.2022 | MFK Karviná | - | Sigma Olomouc | 1:2 | ||||
| 26. Jornada | 20.03.2022 | Sigma Olomouc | - | Slovan Liberec | 1:0 |
República Checa