| 2. Jornada | 25.09.2020 | Sporting Braga | - | CD Santa Clara | 0:1 | ||||
| 9. Jornada | 06.12.2020 | CD Nacional | - | CD Santa Clara | 1:3 | ||||
| 10. Jornada | 21.12.2020 | CD Santa Clara | - | Vitória Guimarães | 0:4 | ||||
| 12. Jornada | 04.01.2021 | CD Santa Clara | - | Benfica | 1:1 | ||||
| 13. Jornada | 09.01.2021 | Boavista | - | CD Santa Clara | 1:1 | ||||
| 14. Jornada | 17.01.2021 | CD Santa Clara | - | FC Famalicão | 1:2 |  |
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| 15. Jornada | 25.01.2021 | Rio Ave FC | - | CD Santa Clara | 1:2 | |
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| 25. Jornada | 03.04.2021 | Oporto | - | CD Santa Clara | 2:1 |
Portugal