| 4. Jornada | 12.08.2018 | Defensor Sporting | - | Rampla Juniors | 2:2 | ||||
| 5. Jornada | 19.08.2018 | Fénix | - | Defensor Sporting | 1:2 | ||||
| 6. Jornada | 26.08.2018 | Defensor Sporting | - | Nacional | 2:0 | ||||
| 7. Jornada | 02.09.2018 | Progreso | - | Defensor Sporting | 0:0 | ||||
| 8. Jornada | 08.09.2018 | CA Cerro | - | Defensor Sporting | 1:1 | ||||
| 9. Jornada | 16.09.2018 | Defensor Sporting | - | Racing | 2:1 | ||||
| 10. Jornada | 23.09.2018 | River Plate | - | Defensor Sporting | 3:2 |  |
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| 11. Jornada | 06.10.2018 | Defensor Sporting | - | Montevideo Wanderers | 3:0 | |
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| 12. Jornada | 14.10.2018 | Liverpool | - | Defensor Sporting | 2:1 | ||||
| 14. Jornada | 28.10.2018 | Boston River | - | Defensor Sporting | 3:1 | ||||
| 15. Jornada | 04.11.2018 | Defensor Sporting | - | Peñarol | 1:2 |
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