| 1. Jornada | 23.07.2021 | Club Necaxa [Sub 20] | - | Santos Laguna [Sub 20] | 3:0 |  |
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| 4. Jornada | 15.08.2021 | Santos Laguna [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 1:2 | ||||
| 5. Jornada | 18.08.2021 | Santos Laguna [Sub 20] | - | Atlas Guadalajara [Sub 20] | 3:1 | ||||
| 10. Jornada | 26.09.2021 | Santos Laguna [Sub 20] | - | CF Monterrey [Sub 20] | 4:1 | ||||
| 16. Jornada | 30.10.2021 | Gallos Blancos [Sub 20] | - | Santos Laguna [Sub 20] | 0:5 |
México