| 4. Jornada | 15.08.2010 | Club San José | - | The Strongest | 3:2 | ||||
| 5. Jornada | 22.08.2010 | CD Guabirá | - | Club San José | 3:1 | ||||
| 6. Jornada | 28.08.2010 | Club San José | - | Real Potosí | 2:3 | ||||
| 7. Jornada | 05.09.2010 | Oriente Petrolero | - | Club San José | 2:1 | ||||
| 8. Jornada | 11.09.2010 | Club San José | - | Club Aurora | 3:3 | ||||
| 22. Jornada | 28.11.2010 | Club San José | - | La Paz FC | 1:0 |
Paraguay