| 1. Jornada | 24.04.2021 | Sporting Kansas City | - | Orlando City | 1:1 | ||||
| 2. Jornada | 02.05.2021 | Orlando City | - | FC Cincinnati | 3:0 | ||||
| 2. Jornada | 17.05.2021 | D.C. United | - | Orlando City | 0:1 | ||||
| 2. Jornada | 23.05.2021 | Orlando City | - | Toronto FC | 1:0 | ||||
| 3. Jornada | 26.06.2021 | Inter Miami CF | - | Orlando City | 1:2 | ||||
| 4. Jornada | 18.07.2021 | Toronto FC | - | Orlando City | 1:1 | ||||
| 4. Jornada | 23.07.2021 | Orlando City | - | Philadelphia Union | 2:1 | ||||
| 4. Jornada | 26.07.2021 | New York City FC | - | Orlando City | 5:0 | ||||
| 4. Jornada | 31.07.2021 | Orlando City | - | Atlanta United FC | 3:2 | ||||
| 5. Jornada | 08.08.2021 | FC Cincinnati | - | Orlando City | 1:1 |  |
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| 5. Jornada | 19.08.2021 | Nashville SC | - | Orlando City | 1:1 | ||||
| 5. Jornada | 22.08.2021 | Orlando City | - | Chicago Fire | 1:0 | ||||
| 5. Jornada | 28.08.2021 | Orlando City | - | Inter Miami CF | 0:0 | ||||
| 6. Jornada | 05.09.2021 | Orlando City | - | Columbus Crew | 3:2 | |
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| 6. Jornada | 11.09.2021 | Atlanta United FC | - | Orlando City | 3:0 | ||||
| 6. Jornada | 19.09.2021 | Philadelphia Union | - | Orlando City | 3:1 | ||||
| 7. Jornada | 25.10.2021 | Orlando City | - | New England Revolution | 2:2 |
Estados Unidos