| 1. Jornada | 06.01.2022 | Alebrijes de Oaxaca | - | Cancún FC | 2:0 | ||||
| 2. Jornada | 12.01.2022 | TM Fútbol Club | - | Alebrijes de Oaxaca | 1:1 | ||||
| 3. Jornada | 20.01.2022 | Alebrijes de Oaxaca | - | Leones Negros | 1:1 |  |
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| 4. Jornada | 27.01.2022 | CF Monterrey II | - | Alebrijes de Oaxaca | 2:0 | ||||
| 5. Jornada | 30.01.2022 | Alebrijes de Oaxaca | - | Atlético Morelia | 1:1 | |
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| 6. Jornada | 02.02.2022 | Tepatitlán | - | Alebrijes de Oaxaca | 1:2 | ||||
| 7. Jornada | 10.02.2022 | Alebrijes de Oaxaca | - | Venados FC | 1:0 | ||||
| 8. Jornada | 17.02.2022 | Cimarrones de Sonora | - | Alebrijes de Oaxaca | 0:1 | ||||
| 9. Jornada | 23.02.2022 | Mineros de Zacatecas | - | Alebrijes de Oaxaca | 4:2 | |
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| 10. Jornada | 02.03.2022 | Alebrijes de Oaxaca | - | Club Celaya | 1:0 | |
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| 12. Jornada | 17.03.2022 | Alebrijes de Oaxaca | - | Coyotes de Tlaxcala | 2:1 | ||||
| 13. Jornada | 23.03.2022 | Tapatío | - | Alebrijes de Oaxaca | 0:1 | ||||
| 14. Jornada | 27.03.2022 | Alebrijes de Oaxaca | - | Dorados de Sinaloa | 5:1 |  |
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| 15. Jornada | 30.03.2022 | Atlante | - | Alebrijes de Oaxaca | 1:0 | ||||
| 16. Jornada | 06.04.2022 | Alebrijes de Oaxaca | - | Pumas Tabasco | 0:0 |
México