| 1. Jornada | 10.07.2022 | Macará | - | Emelec | 1:3 |  |
|||
| 2. Jornada | 16.07.2022 | Orense SC | - | Macará | 1:1 | ||||
| 3. Jornada | 26.07.2022 | Macará | - | Delfín SC | 1:2 | ||||
| 4. Jornada | 31.07.2022 | Macará | - | Universidad Catolica | 1:3 | ||||
| 5. Jornada | 07.08.2022 | Guayaquil City | - | Macará | 0:0 | ||||
| 6. Jornada | 14.08.2022 | Cumbayá | - | Macará | 1:0 | ||||
| 7. Jornada | 21.08.2022 | Macará | - | Aucas | 1:1 | ||||
| 8. Jornada | 27.08.2022 | Deportivo Cuenca | - | Macará | 1:1 | ||||
| 9. Jornada | 04.09.2022 | Macará | - | Mushuc Runa | 3:0 | ||||
| 10. Jornada | 11.09.2022 | Barcelona | - | Macará | 5:3 | ||||
| 11. Jornada | 17.09.2022 | Macará | - | Gualaceo SC | 1:1 | ||||
| 12. Jornada | 25.09.2022 | Independiente del Valle | - | Macará | 1:0 |
Ecuador