| 1. Jornada | 05.09.2021 | UD Melilla | - | CD Toledo | 1:0 | ||||
| 2. Jornada | 12.09.2021 | CD Toledo | - | Águilas FC | 0:1 | ||||
| 3. Jornada | 19.09.2021 | Atlético Mancha Real | - | CD Toledo | 2:0 |  |
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| 4. Jornada | 26.09.2021 | CD Toledo | - | CS Puertollano CF | 1:4 | ||||
| 5. Jornada | 03.10.2021 | CD Toledo | - | CD Marchamalo | 3:2 | ||||
| 6. Jornada | 10.10.2021 | Granada B | - | CD Toledo | 1:1 | ||||
| 9. Jornada | 31.10.2021 | CD Toledo | - | UD Alzira | 1:2 | ||||
| 10. Jornada | 07.11.2021 | UD Socuéllamos | - | CD Toledo | 1:1 | ||||
| 11. Jornada | 14.11.2021 | CD Toledo | - | CA Pulpileño | 0:1 | ||||
| 15. Jornada | 12.12.2021 | CD Toledo | - | CD Eldense | 1:1 | ||||
| 16. Jornada | 19.12.2021 | Hércules CF | - | CD Toledo | 1:0 | ||||
| 17. Jornada | 09.01.2022 | CD Toledo | - | Real Murcia | 0:3 | ||||
| 18. Jornada | 23.01.2022 | CD Toledo | - | UD Melilla | 2:0 | |
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| 19. Jornada | 30.01.2022 | Águilas FC | - | CD Toledo | 1:3 |  |
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| 21. Jornada | 13.02.2022 | CS Puertollano CF | - | CD Toledo | 2:1 |
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