| 1. Jornada | 10.07.2022 | Managua FC | - | Club Deportivo Ocotal | 3:1 |  |
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| 2. Jornada | 17.07.2022 | Club Deportivo Ocotal | - | Real Estelí FC | 0:1 | ||||
| 5. Jornada | 07.08.2022 | Club Deportivo Ocotal | - | Matagalpa FC | 1:1 | |
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| 6. Jornada | 11.08.2022 | Club Deportivo Ocotal | - | H&H Export Sébaco | 2:1 | ||||
| 7. Jornada | 14.08.2022 | ART Municipal Jalapa | - | Club Deportivo Ocotal | 0:3 | ||||
| 8. Jornada | 22.08.2022 | CD Walter Ferretti | - | Club Deportivo Ocotal | 1:3 | ||||
| 4. Jornada | 25.08.2022 | UNAN Managua | - | Club Deportivo Ocotal | 2:0 | |
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| 10. Jornada | 04.09.2022 | Club Deportivo Ocotal | - | Managua FC | 2:1 | ||||
| 11. Jornada | 11.09.2022 | Real Estelí FC | - | Club Deportivo Ocotal | 5:0 | ||||
| 14. Jornada | 27.10.2022 | Matagalpa FC | - | Club Deportivo Ocotal | 1:0 | ||||
| 16. Jornada | 13.11.2022 | Club Deportivo Ocotal | - | ART Municipal Jalapa | 2:3 | |
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| 18. Jornada | 01.12.2022 | Juventus Managua | - | Club Deportivo Ocotal | 9:0 |
Nicaragua