| 1. Jornada | 01.08.2021 | CD Walter Ferretti | - | Real Madriz | 4:1 | ||||
| 5. Jornada | 30.08.2021 | CD Walter Ferretti | - | UNAN Managua | 1:1 | ||||
| 6. Jornada | 02.09.2021 | CD Walter Ferretti | - | Juventus Managua | 2:0 | ||||
| 7. Jornada | 12.09.2021 | H&H Export Sébaco | - | CD Walter Ferretti | 4:8 | ||||
| 3. Jornada | 23.09.2021 | CD Walter Ferretti | - | Diriangén FC | 2:3 |  |
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| 9. Jornada | 27.09.2021 | CD Walter Ferretti | - | Managua FC | 0:0 | |
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| 10. Jornada | 02.10.2021 | Real Madriz | - | CD Walter Ferretti | 3:1 | ||||
| 8. Jornada | 07.10.2021 | Real Estelí FC | - | CD Walter Ferretti | 1:1 | |
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| 11. Jornada | 10.10.2021 | Club Deportivo Ocotal | - | CD Walter Ferretti | 3:0 | |
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| 13. Jornada | 21.10.2021 | CD Walter Ferretti | - | ART Municipal Jalapa | 5:0 | ||||
| 14. Jornada | 25.10.2021 | UNAN Managua | - | CD Walter Ferretti | 0:1 | ||||
| 15. Jornada | 31.10.2021 | CD Walter Ferretti | - | H&H Export Sébaco | 2:1 | |
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| 16. Jornada | 04.11.2021 | Juventus Managua | - | CD Walter Ferretti | 2:2 | ||||
| 17. Jornada | 19.11.2021 | CD Walter Ferretti | - | Real Estelí FC | 4:0 | ||||
| 18. Jornada | 22.11.2021 | Managua FC | - | CD Walter Ferretti | 3:1 |
Nicaragua