| 1. Jornada | 15.05.2021 | Villa Española | - | Progreso | 0:0 | ||||
| 2. Jornada | 23.05.2021 | Progreso | - | Nacional | 1:3 |  |
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| 3. Jornada | 29.05.2021 | Cerrito | - | Progreso | 0:0 | |
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| 4. Jornada | 04.06.2021 | Progreso | - | Liverpool | 1:3 | ||||
| 5. Jornada | 12.06.2021 | River Plate | - | Progreso | 4:0 | ||||
| 10. Jornada | 11.07.2021 | Fénix | - | Progreso | 2:1 | ||||
| 11. Jornada | 16.07.2021 | Progreso | - | Boston River | 1:0 | ||||
| 12. Jornada | 31.07.2021 | Montevideo Wanderers | - | Progreso | 2:0 | ||||
| 13. Jornada | 06.08.2021 | Progreso | - | Rentistas | 2:2 | ||||
| 14. Jornada | 15.08.2021 | Peñarol | - | Progreso | 1:0 | ||||
| 15. Jornada | 20.08.2021 | Progreso | - | Montevideo City Torque | 1:4 | |
Uruguay