| 1. Jornada | 15.05.2021 | Villa Española | - | Progreso | 0:0 |  |
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| 2. Jornada | 24.05.2021 | Sud América | - | Villa Española | 2:1 | ||||
| 3. Jornada | 29.05.2021 | Villa Española | - | Plaza Colonia | 1:3 | ||||
| 4. Jornada | 07.06.2021 | Fénix | - | Villa Española | 1:0 | ||||
| 5. Jornada | 14.06.2021 | Villa Española | - | Boston River | 2:2 | |
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| 6. Jornada | 19.06.2021 | Montevideo Wanderers | - | Villa Española | 3:0 | |
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| 7. Jornada | 23.06.2021 | Villa Española | - | Rentistas | 0:1 |  |
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| 9. Jornada | 03.07.2021 | Villa Española | - | Montevideo City Torque | 2:3 |  |
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| 10. Jornada | 10.07.2021 | Villa Española | - | Deportivo Maldonado | 2:0 | ||||
| 12. Jornada | 02.08.2021 | Villa Española | - | Cerrito | 1:1 | |
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| 13. Jornada | 08.08.2021 | Liverpool | - | Villa Española | 2:2 | |
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| 14. Jornada | 15.08.2021 | Villa Española | - | River Plate | 1:1 | ||||
| 15. Jornada | 22.08.2021 | Cerro Largo | - | Villa Española | 3:1 |
Uruguay