| 1. Jornada | 10.07.2022 | Gualaceo SC | - | LDU Quito | 0:1 | ||||
| 2. Jornada | 16.07.2022 | Cumbayá | - | Gualaceo SC | 1:2 | ||||
| 5. Jornada | 09.08.2022 | Gualaceo SC | - | 9 de Octubre | 1:0 | ||||
| 7. Jornada | 20.08.2022 | Gualaceo SC | - | Técnico Universitario | 0:3 | ||||
| 8. Jornada | 28.08.2022 | Mushuc Runa | - | Gualaceo SC | 2:0 | ||||
| 9. Jornada | 04.09.2022 | Gualaceo SC | - | Barcelona | 2:1 | ||||
| 10. Jornada | 10.09.2022 | Orense SC | - | Gualaceo SC | 4:1 |  |
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| 11. Jornada | 17.09.2022 | Macará | - | Gualaceo SC | 1:1 | ||||
| 12. Jornada | 01.10.2022 | Gualaceo SC | - | Universidad Catolica | 0:1 | |
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| 13. Jornada | 09.10.2022 | Guayaquil City | - | Gualaceo SC | 1:0 | ||||
| 14. Jornada | 16.10.2022 | Gualaceo SC | - | Delfín SC | 2:1 |
Ecuador