| 7. Jornada | 30.08.2020 | Santos Laguna [Sub 20] | - | Gallos Blancos [Sub 20] | 3:1 | ||||
| 8. Jornada | 04.09.2020 | FC Juárez [Sub 20] | - | Santos Laguna [Sub 20] | 0:1 |  |
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| 11. Jornada | 20.09.2020 | Deportivo Toluca [Sub 20] | - | Santos Laguna [Sub 20] | 1:0 | ||||
| 12. Jornada | 27.09.2020 | Santos Laguna [Sub 20] | - | Club Tijuana [Sub 20] | 5:1 | ||||
| 13. Jornada | 02.10.2020 | Puebla FC [Sub 20] | - | Santos Laguna [Sub 20] | 2:1 | ||||
| 14. Jornada | 18.10.2020 | Santos Laguna [Sub 20] | - | CF Pachuca [Sub 20] | 1:2 | |
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| 15. Jornada | 25.10.2020 | Santos Laguna [Sub 20] | - | Atlético San Luis [Sub 20] | 2:1 | |
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| 16. Jornada | 02.11.2020 | Club León [Sub 20] | - | Santos Laguna [Sub 20] | 4:3 | |
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| 17. Jornada | 08.11.2020 | Santos Laguna [Sub 20] | - | Mazatlán FC [Sub 20] | 4:1 | |
México