| 2. Jornada | 19.08.2016 | Manchester United | - | Southampton | 2:0 | ||||
| 4. Jornada | 10.09.2016 | Arsenal | - | Southampton | 2:1 | ||||
| 5. Jornada | 18.09.2016 | Southampton | - | Swansea City | 1:0 | ||||
| 8. Jornada | 16.10.2016 | Southampton | - | Burnley FC | 3:1 | ||||
| 9. Jornada | 23.10.2016 | Manchester City | - | Southampton | 1:1 |  |
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| 10. Jornada | 30.10.2016 | Southampton | - | Chelsea | 0:2 | ||||
| 11. Jornada | 06.11.2016 | Hull City | - | Southampton | 2:1 | |
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| 13. Jornada | 27.11.2016 | Southampton | - | Everton | 1:0 | ||||
| 15. Jornada | 11.12.2016 | Southampton | - | Middlesbrough | 1:0 | ||||
| 17. Jornada | 18.12.2016 | Bournemouth | - | Southampton | 1:3 | |
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| 20. Jornada | 02.01.2017 | Everton | - | Southampton | 3:0 | ||||
| 22. Jornada | 22.01.2017 | Southampton | - | Leicester City | 3:0 | ||||
| 23. Jornada | 31.01.2017 | Swansea City | - | Southampton | 2:1 | ||||
| 27. Jornada | 04.03.2017 | Watford FC | - | Southampton | 3:4 | ||||
| 32. Jornada | 08.04.2017 | West Bromwich Albion | - | Southampton | 0:1 |  |
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| 37. Jornada | 13.05.2017 | Middlesbrough | - | Southampton | 1:2 |
Países Bajos