| 3. Jornada | 02.02.2008 | Veracruz (old) | - | Santos Laguna | 1:1 | ||||
| 4. Jornada | 10.02.2008 | Santos Laguna | - | CF Pachuca | 2:1 |  |
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| 6. Jornada | 17.02.2008 | Santos Laguna | - | Atlante | 3:0 | ||||
| 7. Jornada | 24.02.2008 | CF América | - | Santos Laguna | 0:1 | ||||
| 9. Jornada | 09.03.2008 | Puebla FC | - | Santos Laguna | 3:3 | ||||
| 10. Jornada | 16.03.2008 | Santos Laguna | - | Jaguares Chiapas | 1:3 | ||||
| 11. Jornada | 23.03.2008 | Pumas UNAM | - | Santos Laguna | 1:1 | |
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| 15. Jornada | 20.04.2008 | Santos Laguna | - | Club Necaxa | 1:1 |
México