| 6. Jornada | 19.02.2022 | Club León [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 3:0 | ||||
| 7. Jornada | 25.02.2022 | Club Necaxa [Sub 20] | - | Club León [Sub 20] | 0:3 |  |
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| 8. Jornada | 01.03.2022 | Club León [Sub 20] | - | CF Monterrey [Sub 20] | 1:2 | ||||
| 10. Jornada | 12.03.2022 | Club León [Sub 20] | - | UANL Tigres [Sub 20] | 2:1 | ||||
| 12. Jornada | 03.04.2022 | Club León [Sub 20] | - | Gallos Blancos [Sub 20] | 2:1 | |
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| 14. Jornada | 16.04.2022 | Club León [Sub 20] | - | Puebla FC [Sub 20] | 4:1 | |
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| 16. Jornada | 24.04.2022 | Santos Laguna [Sub 20] | - | Club León [Sub 20] | 0:3 | |
México