| 1. Jornada | 18.01.2021 | Plaza Colonia | - | Liverpool | 0:0 |  |
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| 2. Jornada | 21.01.2021 | Plaza Colonia | - | Progreso | 0:1 | ||||
| 4. Jornada | 04.02.2021 | Plaza Colonia | - | CA Cerro | 2:1 | |
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| 6. Jornada | 10.02.2021 | Plaza Colonia | - | Danubio | 3:0 | ||||
| 8. Jornada | 19.02.2021 | Plaza Colonia | - | Boston River | 3:0 | ||||
| 10. Jornada | 01.03.2021 | Plaza Colonia | - | Rentistas | 5:0 | |
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| 12. Jornada | 12.03.2021 | Plaza Colonia | - | Montevideo Wanderers | 3:0 |
Uruguay