| 1. Jornada | 02.06.2021 | Central Español | - | Danubio | 0:0 | ||||
| 2. Jornada | 16.06.2021 | Danubio | - | Atenas | 2:1 | ||||
| 3. Jornada | 20.06.2021 | Racing | - | Danubio | 2:1 |  |
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| 4. Jornada | 26.06.2021 | Danubio | - | Villa Teresa | 1:0 | |
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| 9. Jornada | 29.07.2021 | Danubio | - | Rocha | 1:0 | ||||
| 10. Jornada | 06.08.2021 | CA Cerro | - | Danubio | 1:1 | |
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| 11. Jornada | 14.08.2021 | Danubio | - | Defensor Sporting | 0:1 | ||||
| 14. Jornada | 29.09.2021 | Danubio | - | Racing | 2:0 |
Uruguay