| 2. Jornada | 15.01.2022 | Atlas Guadalajara [Sub 20] | - | Atlético San Luis [Sub 20] | 1:3 | ||||
| 3. Jornada | 27.01.2022 | CF América [Sub 20] | - | Atlas Guadalajara [Sub 20] | 3:1 | ||||
| 4. Jornada | 06.02.2022 | Atlas Guadalajara [Sub 20] | - | Santos Laguna [Sub 20] | 0:1 | ||||
| 5. Jornada | 11.02.2022 | Puebla FC [Sub 20] | - | Atlas Guadalajara [Sub 20] | 1:2 |  |
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| 11. Jornada | 20.03.2022 | Atlas Guadalajara [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 1:2 | |
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| 12. Jornada | 02.04.2022 | Cruz Azul [Sub 20] | - | Atlas Guadalajara [Sub 20] | 1:0 | ||||
| 13. Jornada | 07.04.2022 | Atlas Guadalajara [Sub 20] | - | Club Necaxa [Sub 20] | 1:1 | ||||
| 14. Jornada | 14.04.2022 | Atlas Guadalajara [Sub 20] | - | Mazatlán FC [Sub 20] | 3:1 |  |
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| 15. Jornada | 20.04.2022 | CF Monterrey [Sub 20] | - | Atlas Guadalajara [Sub 20] | 0:0 | ||||
| 16. Jornada | 24.04.2022 | Deportivo Toluca [Sub 20] | - | Atlas Guadalajara [Sub 20] | 2:1 | |
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| 17. Jornada | 30.04.2022 | Atlas Guadalajara [Sub 20] | - | UANL Tigres [Sub 20] | 0:0 |
México