| 2. Jornada | 02.08.2020 | Deportivo Toluca | - | Atlético San Luis | 3:2 |  |
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| 3. Jornada | 10.08.2020 | Atlético San Luis | - | Atlas Guadalajara | 1:1 | ||||
| 4. Jornada | 13.08.2020 | Club Tijuana | - | Atlético San Luis | 0:2 | |
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| 6. Jornada | 24.08.2020 | Atlético San Luis | - | Cruz Azul | 1:3 | ||||
| 7. Jornada | 30.08.2020 | Atlético San Luis | - | CF América | 1:2 | ||||
| 8. Jornada | 04.09.2020 | CF Pachuca | - | Atlético San Luis | 3:1 | ||||
| 9. Jornada | 09.09.2020 | Atlético San Luis | - | Club Necaxa | 2:1 | ||||
| 10. Jornada | 13.09.2020 | Pumas UNAM | - | Atlético San Luis | 3:0 | ||||
| 11. Jornada | 21.09.2020 | Atlético San Luis | - | CF Monterrey | 1:2 | ||||
| 12. Jornada | 28.09.2020 | Atlético San Luis | - | Club León | 0:2 | ||||
| 13. Jornada | 04.10.2020 | UANL Tigres | - | Atlético San Luis | 3:0 | |
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| 14. Jornada | 16.10.2020 | Atlético San Luis | - | Gallos Blancos | 2:1 | ||||
| 15. Jornada | 26.10.2020 | Santos Laguna | - | Atlético San Luis | 2:1 | ||||
| 16. Jornada | 30.10.2020 | Atlético San Luis | - | Mazatlán FC | 0:5 | ||||
| 17. Jornada | 07.11.2020 | Puebla FC | - | Atlético San Luis | 1:0 |
México