| 3. Jornada | 05.02.2020 | Real Santa Cruz | - | Club San José | 1:1 | ||||
| 5. Jornada | 09.02.2020 | Always Ready | - | Real Santa Cruz | 6:0 | ||||
| 10. Jornada | 03.03.2020 | Royal Pari | - | Real Santa Cruz | 0:2 |  |
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| 11. Jornada | 06.03.2020 | Real Santa Cruz | - | Nacional Potosí | 2:1 | ||||
| 14. Jornada | 30.11.2020 | Real Santa Cruz | - | Blooming | 0:2 | ||||
| 15. Jornada | 03.12.2020 | The Strongest | - | Real Santa Cruz | 4:2 | ||||
| 16. Jornada | 07.12.2020 | Club San José | - | Real Santa Cruz | 4:1 | ||||
| 17. Jornada | 09.12.2020 | Real Santa Cruz | - | Real Potosí | 3:1 | ||||
| 18. Jornada | 12.12.2020 | Real Santa Cruz | - | Always Ready | 0:3 | ||||
| 19. Jornada | 14.12.2020 | Real Santa Cruz | - | Jorge Wilstermann | 1:3 | ||||
| 20. Jornada | 17.12.2020 | Oriente Petrolero | - | Real Santa Cruz | 3:2 | ||||
| 21. Jornada | 19.12.2020 | Real Santa Cruz | - | Atlético Palmaflor | 2:1 | |
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| 22. Jornada | 22.12.2020 | Bolívar | - | Real Santa Cruz | 4:0 | ||||
| 23. Jornada | 24.12.2020 | Real Santa Cruz | - | Royal Pari | 2:4 | |
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| 24. Jornada | 27.12.2020 | Nacional Potosí | - | Real Santa Cruz | 1:0 | |
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| 25. Jornada | 29.12.2020 | Real Santa Cruz | - | CD Guabirá | 4:4 | |
Bolivia