| 1. Jornada | 12.09.2020 | FC Twente | - | Fortuna Sittard | 2:0 | ||||
| 2. Jornada | 19.09.2020 | Fortuna Sittard | - | sc Heerenveen | 1:3 | ||||
| 3. Jornada | 26.09.2020 | Fortuna Sittard | - | AZ Alkmaar | 3:3 |  |
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| 4. Jornada | 04.10.2020 | PSV | - | Fortuna Sittard | 2:0 | ||||
| 5. Jornada | 18.10.2020 | FC Emmen | - | Fortuna Sittard | 2:2 | ||||
| 6. Jornada | 25.10.2020 | Fortuna Sittard | - | FC Groningen | 1:3 | ||||
| 7. Jornada | 31.10.2020 | AFC Ajax | - | Fortuna Sittard | 5:2 | ||||
| 8. Jornada | 06.11.2020 | Fortuna Sittard | - | PEC Zwolle | 2:2 | ||||
| 9. Jornada | 22.11.2020 | Fortuna Sittard | - | Feyenoord | 1:3 | ||||
| 10. Jornada | 29.11.2020 | Vitesse | - | Fortuna Sittard | 2:0 | ||||
| 13. Jornada | 19.12.2020 | FC Utrecht | - | Fortuna Sittard | 1:1 | ||||
| 15. Jornada | 10.01.2021 | sc Heerenveen | - | Fortuna Sittard | 1:3 | ||||
| 17. Jornada | 16.01.2021 | PEC Zwolle | - | Fortuna Sittard | 0:2 | ||||
| 19. Jornada | 27.01.2021 | RKC Waalwijk | - | Fortuna Sittard | 1:2 | ||||
| 20. Jornada | 30.01.2021 | Fortuna Sittard | - | VVV-Venlo | 3:2 |
Países Bajos