| 1. Jornada | 18.01.2021 | Boston River | - | Deportivo Maldonado | 5:0 | ||||
| 2. Jornada | 22.01.2021 | Rentistas | - | Boston River | 0:1 |  |
|||
| 3. Jornada | 29.01.2021 | Boston River | - | Cerro Largo | 2:1 |  |
|||
| 4. Jornada | 04.02.2021 | Montevideo Wanderers | - | Boston River | 2:2 | ||||
| 5. Jornada | 07.02.2021 | Boston River | - | Peñarol | 1:2 | ||||
| 6. Jornada | 11.02.2021 | River Plate | - | Boston River | 3:1 | ||||
| 7. Jornada | 15.02.2021 | Boston River | - | Montevideo City Torque | 0:3 | ||||
| 8. Jornada | 19.02.2021 | Plaza Colonia | - | Boston River | 3:0 | |
|||
| 10. Jornada | 28.02.2021 | Fénix | - | Boston River | 2:1 | |
|||
| 11. Jornada | 06.03.2021 | Boston River | - | CA Cerro | 2:0 | ||||
| 12. Jornada | 12.03.2021 | Defensor Sporting | - | Boston River | 1:2 | ||||
| 13. Jornada | 19.03.2021 | Boston River | - | Danubio | 1:5 | |
|||
| 14. Jornada | 25.03.2021 | Nacional | - | Boston River | 1:2 | ||||
| 15. Jornada | 29.03.2021 | Boston River | - | Liverpool | 1:0 |
Uruguay