| 4. Jornada | 17.02.2010 | Guaraní | - | Tacuary | 5:2 |  |
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| 5. Jornada | 21.02.2010 | Sportivo Luqueño | - | Guaraní | 1:2 | ||||
| 6. Jornada | 27.02.2010 | Guaraní | - | 3 de Febrero | 1:1 | ||||
| 7. Jornada | 06.03.2010 | Club Nacional | - | Guaraní | 1:0 | ||||
| 9. Jornada | 17.03.2010 | Sport Colombia | - | Guaraní | 1:3 | ||||
| 10. Jornada | 21.03.2010 | Guaraní | - | Cerro Porteño | 1:2 | ||||
| 12. Jornada | 04.04.2010 | Libertad | - | Guaraní | 2:1 |
Paraguay