| 2. Jornada | 19.08.2016 | Manchester United | - | Southampton | 2:0 | ||||
| 3. Jornada | 27.08.2016 | Southampton | - | Sunderland | 1:1 | ||||
| 4. Jornada | 10.09.2016 | Arsenal | - | Southampton | 2:1 |  |
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| 5. Jornada | 18.09.2016 | Southampton | - | Swansea City | 1:0 | ||||
| 6. Jornada | 25.09.2016 | West Ham United | - | Southampton | 0:3 | ||||
| 7. Jornada | 02.10.2016 | Leicester City | - | Southampton | 0:0 | ||||
| 8. Jornada | 16.10.2016 | Southampton | - | Burnley FC | 3:1 | ||||
| 9. Jornada | 23.10.2016 | Manchester City | - | Southampton | 1:1 | ||||
| 10. Jornada | 30.10.2016 | Southampton | - | Chelsea | 0:2 | ||||
| 11. Jornada | 06.11.2016 | Hull City | - | Southampton | 2:1 | ||||
| 12. Jornada | 19.11.2016 | Southampton | - | Liverpool | 0:0 | ||||
| 13. Jornada | 27.11.2016 | Southampton | - | Everton | 1:0 | ||||
| 14. Jornada | 03.12.2016 | Crystal Palace | - | Southampton | 3:0 | ||||
| 15. Jornada | 11.12.2016 | Southampton | - | Middlesbrough | 1:0 | |
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| 16. Jornada | 14.12.2016 | Stoke City | - | Southampton | 0:0 | ||||
| 18. Jornada | 28.12.2016 | Southampton | - | Tottenham Hotspur | 1:4 | ||||
| 20. Jornada | 02.01.2017 | Everton | - | Southampton | 3:0 |
Portugal
