| 9. Jornada | 04.04.2021 | Alianza | - | San Francisco FC | 1:1 | ||||
| 10. Jornada | 10.04.2021 | San Francisco FC | - | Sporting San Miguelito | 2:0 | ||||
| 11. Jornada | 15.04.2021 | Árabe Unido | - | San Francisco FC | 1:1 | ||||
| 12. Jornada | 21.04.2021 | Atlético Chiriquí | - | San Francisco FC | 3:0 | ||||
| 13. Jornada | 24.04.2021 | San Francisco FC | - | UD Universitario | 0:0 | ||||
| 14. Jornada | 28.04.2021 | Independiente de La Chorrera | - | San Francisco FC | 2:0 |  |
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| 15. Jornada | 03.05.2021 | San Francisco FC | - | Herrera FC | 0:0 | |
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| 16. Jornada | 09.05.2021 | Veraguas Club Deportivo | - | San Francisco FC | 2:1 | |
Panamá