| 2. Jornada | 02.07.2022 | Puebla FC [] | - | FC Juárez [] | 4:0 | ||||
| 1. Jornada | 13.07.2022 | CF Pachuca [] | - | Puebla FC [] | 3:0 | ||||
| 5. Jornada | 23.07.2022 | Puebla FC [] | - | Cruz Azul [] | 2:1 | ||||
| 7. Jornada | 06.08.2022 | Puebla FC [] | - | Deportivo Toluca [] | 0:3 | ||||
| 3. Jornada | 10.08.2022 | CF América [] | - | Puebla FC [] | 4:3 | ||||
| 8. Jornada | 13.08.2022 | Club Necaxa [] | - | Puebla FC [] | 1:0 | ||||
| 9. Jornada | 20.08.2022 | Puebla FC [] | - | Pumas UNAM [] | 1:2 | ||||
| 10. Jornada | 27.08.2022 | Puebla FC [] | - | CF Pachuca [] | 1:1 | ||||
| 11. Jornada | 03.09.2022 | FC Juárez [] | - | Puebla FC [] | 2:1 | ||||
| 12. Jornada | 10.09.2022 | Puebla FC [] | - | CF América [] | 1:4 | ||||
| 14. Jornada | 24.09.2022 | Cruz Azul [] | - | Puebla FC [] | 1:1 | ||||
| 15. Jornada | 01.10.2022 | Puebla FC [] | - | Gallos Blancos [] | 2:2 | ||||
| 16. Jornada | 08.10.2022 | Deportivo Toluca [] | - | Puebla FC [] | 3:1 | ||||
| 17. Jornada | 15.10.2022 | Puebla FC [] | - | Club Necaxa [] | 1:5 |
México