| 2. Jornada | 10.07.2022 | Club León [Sub 18] | - | Pumas UNAM [Sub 18] | 1:2 |  |
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| 5. Jornada | 27.07.2022 | Pumas UNAM [Sub 18] | - | Mazatlán FC [Sub 18] | 2:0 | |
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| 6. Jornada | 30.07.2022 | Pumas UNAM [Sub 18] | - | CF Monterrey [Sub 18] | 2:1 | |
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| 7. Jornada | 06.08.2022 | Puebla FC [Sub 18] | - | Pumas UNAM [Sub 18] | 1:0 | ||||
| 8. Jornada | 13.08.2022 | Pumas UNAM [Sub 18] | - | CF América [Sub 18] | 1:2 | |
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| 9. Jornada | 18.08.2022 | Atlético San Luis [Sub 18] | - | Pumas UNAM [Sub 18] | 2:1 | |
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| 10. Jornada | 21.08.2022 | Pumas UNAM [Sub 18] | - | Santos Laguna [Sub 18] | 2:0 | |
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| 16. Jornada | 24.08.2022 | Pumas UNAM [Sub 18] | - | UANL Tigres [Sub 18] | 1:1 | ||||
| 11. Jornada | 27.08.2022 | Deportivo Guadalajara [Sub 18] | - | Pumas UNAM [Sub 18] | 1:0 |  |
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| 12. Jornada | 03.09.2022 | Atlas Guadalajara [Sub 18] | - | Pumas UNAM [Sub 18] | 1:1 | |
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| 13. Jornada | 07.09.2022 | Pumas UNAM [Sub 18] | - | Gallos Blancos [Sub 18] | 1:0 | |
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| 14. Jornada | 10.09.2022 | Deportivo Toluca [Sub 18] | - | Pumas UNAM [Sub 18] | 0:1 | ||||
| 15. Jornada | 18.09.2022 | Pumas UNAM [Sub 18] | - | Cruz Azul [Sub 18] | 0:0 | ||||
| 17. Jornada | 30.09.2022 | FC Juárez [Sub 18] | - | Pumas UNAM [Sub 18] | 1:1 |
México