| 1. Jornada | 23.01.2022 | Juventus Managua | - | Managua FC | 1:2 |  |
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| 2. Jornada | 05.02.2022 | Managua FC | - | ART Municipal Jalapa | 3:0 | |
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| 3. Jornada | 10.02.2022 | Real Estelí FC | - | Managua FC | 1:2 | |
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| 4. Jornada | 14.02.2022 | Managua FC | - | H&H Export Sébaco | 3:2 | ||||
| 5. Jornada | 20.02.2022 | Diriangén FC | - | Managua FC | 0:2 | ||||
| 6. Jornada | 28.02.2022 | Managua FC | - | UNAN Managua | 3:3 |  |
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| 7. Jornada | 04.03.2022 | Managua FC | - | Club Deportivo Ocotal | 1:1 | ||||
| 8. Jornada | 07.03.2022 | Real Madriz | - | Managua FC | 1:0 | ||||
| 9. Jornada | 11.03.2022 | Managua FC | - | CD Walter Ferretti | 2:1 | ||||
| 10. Jornada | 14.03.2022 | Managua FC | - | Juventus Managua | 0:2 | |
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| 12. Jornada | 03.04.2022 | Managua FC | - | Real Estelí FC | 1:2 | ||||
| 13. Jornada | 06.04.2022 | H&H Export Sébaco | - | Managua FC | 2:0 | ||||
| 16. Jornada | 25.04.2022 | UNAN Managua | - | Managua FC | 0:1 | |
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| 17. Jornada | 28.04.2022 | Managua FC | - | Real Madriz | 3:0 | ||||
| 18. Jornada | 02.05.2022 | CD Walter Ferretti | - | Managua FC | 1:0 |
Nicaragua