| 2. Jornada | 24.09.2021 | CD Zap | - | Escorpiones | 2:1 |  |
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| 3. Jornada | 02.10.2021 | Cafetaleros de Chiapas | - | CD Zap | 2:1 | ||||
| 4. Jornada | 08.10.2021 | CD Zap | - | Inter Playa | 1:5 | |
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| 5. Jornada | 13.10.2021 | CD Zap | - | Inter de Querétaro | 2:1 | ||||
| 6. Jornada | 17.10.2021 | Montañeses FC | - | CD Zap | 1:0 |  |
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| 7. Jornada | 22.10.2021 | CD Zap | - | Leviatán FC | 3:0 | ||||
| 8. Jornada | 31.10.2021 | Sporting Canamy | - | CD Zap | 0:1 | ||||
| 9. Jornada | 05.11.2021 | CD Zap | - | Yalmakan FC | 1:3 | ||||
| 10. Jornada | 11.11.2021 | Lobos ULMX | - | CD Zap | 1:2 | ||||
| 11. Jornada | 14.11.2021 | CD Zap | - | Reboceros de La Piedad | 0:2 | ||||
| 12. Jornada | 20.11.2021 | Deportivo Dongu | - | CD Zap | 0:2 | ||||
| 13. Jornada | 26.11.2021 | CD Zap | - | Cañoneros FC | 6:2 | |
México