| 1. Jornada | 18.07.2021 | River Plate | - | Colón de Santa Fe | 1:2 | ||||
| 2. Jornada | 25.07.2021 | River Plate | - | Unión de Santa Fe | 4:0 | ||||
| 3. Jornada | 29.07.2021 | CA Lanús | - | River Plate | 0:3 | ||||
| 4. Jornada | 01.08.2021 | River Plate | - | Huracán | 1:1 | ||||
| 5. Jornada | 08.08.2021 | Godoy Cruz | - | River Plate | 2:1 |  |
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| 6. Jornada | 14.08.2021 | River Plate | - | Vélez Sarsfield | 2:0 | ||||
| 7. Jornada | 23.08.2021 | Gimnasia de La Plata | - | River Plate | 1:1 | ||||
| 9. Jornada | 31.08.2021 | Sarmiento de Junín | - | River Plate | 1:2 | |
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| 10. Jornada | 06.09.2021 | River Plate | - | Independiente | 1:1 | ||||
| 15. Jornada | 09.10.2021 | Banfield | - | River Plate | 0:1 | ||||
| 18. Jornada | 26.10.2021 | River Plate | - | Argentinos Juniors | 3:0 | ||||
| 21. Jornada | 22.11.2021 | Platense | - | River Plate | 0:1 | ||||
| 23. Jornada | 28.11.2021 | Rosario Central | - | River Plate | 2:2 | ||||
| 25. Jornada | 11.12.2021 | Atlético Tucumán | - | River Plate | 1:1 |
Argentina