| 2. Jornada | 12.02.2022 | San Francisco FC | - | Independiente de La Chorrera | 2:0 |  |
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| 3. Jornada | 20.02.2022 | Atlético Chiriquí | - | San Francisco FC | 2:1 | |
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| 4. Jornada | 26.02.2022 | San Francisco FC | - | UD Universitario | 0:1 | ||||
| 8. Jornada | 21.03.2022 | Tauro FC | - | San Francisco FC | 1:0 | ||||
| 9. Jornada | 26.03.2022 | San Francisco FC | - | Sporting San Miguelito | 0:1 | ||||
| 10. Jornada | 02.04.2022 | San Francisco FC | - | Plaza Amador | 2:2 | ||||
| 11. Jornada | 09.04.2022 | Potros del Este | - | San Francisco FC | 0:0 | ||||
| 13. Jornada | 24.04.2022 | Independiente de La Chorrera | - | San Francisco FC | 1:4 | ||||
| 14. Jornada | 27.04.2022 | San Francisco FC | - | Atlético Chiriquí | 2:2 |  |
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| 15. Jornada | 30.04.2022 | UD Universitario | - | San Francisco FC | 0:1 | ||||
| 12. Jornada | 05.05.2022 | Veraguas United | - | San Francisco FC | 0:2 | ||||
| 16. Jornada | 08.05.2022 | San Francisco FC | - | Herrera FC | 3:1 |
Panamá