| 1. Jornada | 12.01.2025 | Caja Oblatos | - | Santiago FC | 2:1 | ||||
| 2. Jornada | 18.01.2025 | Santiago FC | - | CD Ayense | 3:2 | ||||
| 3. Jornada | 25.01.2025 | Cordobés FC | - | Santiago FC | 2:0 | ||||
| 4. Jornada | 01.02.2025 | Santiago FC | - | Huracanes Izcalli | 1:0 | ||||
| 5. Jornada | 08.02.2025 | Santiago FC | - | Artesanos Metepec | 3:0 |  |
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| 6. Jornada | 14.02.2025 | Real Zamora | - | Santiago FC | 1:2 | ||||
| 9. Jornada | 08.03.2025 | Santiago FC | - | CDM FC | 1:1 | ||||
| 10. Jornada | 14.03.2025 | Atlético Pachuca | - | Santiago FC | 0:0 | ||||
| 11. Jornada | 22.03.2025 | Santiago FC | - | Club Calor | 2:0 |
México