| 1. Jornada | 06.01.2022 | Atlético San Luis [Sub 18] | - | CF Pachuca [Sub 18] | 1:0 | ||||
| 4. Jornada | 05.02.2022 | Club Necaxa [Sub 18] | - | CF Pachuca [Sub 18] | 0:1 | ||||
| 5. Jornada | 14.02.2022 | CF Pachuca [Sub 18] | - | Gallos Blancos [Sub 18] | 0:1 | ||||
| 6. Jornada | 20.02.2022 | CF América [Sub 18] | - | CF Pachuca [Sub 18] | 3:0 |  |
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| 7. Jornada | 24.02.2022 | CF Pachuca [Sub 18] | - | Mazatlán FC [Sub 18] | 3:1 | ||||
| 8. Jornada | 02.03.2022 | Atlas Guadalajara [Sub 18] | - | CF Pachuca [Sub 18] | 2:1 |  |
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| 11. Jornada | 19.03.2022 | CF Pachuca [Sub 18] | - | Cruz Azul [Sub 18] | 3:2 | ||||
| 9. Jornada | 23.03.2022 | CF Pachuca [Sub 18] | - | UANL Tigres [Sub 18] | 4:0 | ||||
| 12. Jornada | 03.04.2022 | Santos Laguna [Sub 18] | - | CF Pachuca [Sub 18] | 3:1 |
México