| 4. Jornada | 14.08.2021 | Deportivo Guadalajara [Sub 16] | - | Santos Laguna [Sub 16] | 0:0 |  |
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| 8. Jornada | 11.09.2021 | Santos Laguna [Sub 16] | - | Mazatlán FC [Sub 16] | 4:2 | ||||
| 10. Jornada | 25.09.2021 | Santos Laguna [Sub 16] | - | Atlas Guadalajara [Sub 16] | 1:2 | ||||
| 12. Jornada | 09.10.2021 | Mazatlán FC [Sub 16] | - | Santos Laguna [Sub 16] | 1:2 |
México